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L-arginine more commonly causes gastrointestinal issues, including diarrhea, nausea, and abdominal pain, particularly at higher doses

This degradation can result in suboptimal glycaemic control, leading to elevated blood glucose levels (hyperglycaemia) and potentially increasing the risk of diabetes-related complications such as cardiovascular disease, neuropathy, nephropathy, and retinopathy

Some Cigna plans also require step therapy, meaning the patient must try a lower-cost medication such as Contrave before the insurer will approve a GLP-1 agonist

It covers regular progress check-ins where your provider reviews your response and adjusts your protocol

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