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Glucagon enhances multiple steps in this pathway: Increased lipolysis: Glucagon activates hormone-sensitive lipase in adipose tissue, releasing more fatty acids into circulation Reduced lipogenesis: Glucagon suppresses the enzymes responsible for creating new fat from carbohydrates Enhanced hepatic oxidation: Glucagon upregulates liver enzymes involved in fatty acid oxidation Ketogenesis: When fat oxidation exceeds the citric acid cycle capacity, excess acetyl-CoA is converted to ketone bodies, an alternative fuel source The net effect is a metabolic state favoring fat breakdown over fat storage

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Because Pendulum can increase GLP-1 production, and GLP-1 affects insulin secretion, combining the supplement with insulin or sulfonylureas could theoretically increase hypoglycemia risk

10.1074/jbc.M404795200 49 KogureK.ZhangY

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