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As such, the GLP-1 pathway has become a major therapeutic target in diabetes, obesity, and cardiometabolic research

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An analysis of insurance claims for GLP-1 weight-loss therapy (in patients without diabetes) found only 29% were still on the medication at 1 year, and a mere 15% at 2 years (source)

Collectively, these results highlight the cognitive effects of GLP-1R agonists in response to food cues, implying that the effects of GLP-1R agonists on satiation and satiety extend to cognitive processes

Niacinamide (vitamin B3) supports NAD+ production, which is involved in cellular energy metabolism and DNA repair