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10.1007/s00726-013-1568-z 32 MertinsP.ManiD
Several factors are recognized to contribute to its development including an overgeneration of reactive oxygen species (ROS)
The answer, based on current scientific literature, is nuanced but positive
Pre-infusion CAR T cells of long-term responders (LTR) have increased oxidative phosphorylation, fatty acid oxidation, and pentose phosphate pathway activities, higher mitochondrial mass, tighter cristae, and lower mTOR expression compared to products of short-term responders
Through disruption of hydrophobic lipid-lipid and lipid-protein interactions, this change may result in structural changes to biomembranes and lipoproteins
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