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Despite the discovery of numerous potent and selective Na v channel inhibitors, which are pharmacologically interesting, very few of these inhibitors have resulted in effective pain relief in preclinical models or human clinical trials (Eagles et al., 2022)

Together, these findings position NRF2 as the central mediator of melatonin-induced metabolic reprogramming and functional suppression in ILC2s and identify NRF2 as a therapeutically actionable target

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(x) The mechanism by which L-carnosine benefits children with autism is largely unknown