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symptoms include right upper abdominal pain, particularly after eating Hypoglycaemia : More likely if taking Wegovy alongside insulin or sulphonylureas for diabetes [1] [17] Acute kidney injury : Usually related to severe dehydration from vomiting or diarrhoea Diabetic retinopathy complications : Patients with pre-existing diabetic eye disease should be monitored The UK MHRA/EMC SmPC includes a precaution regarding thyroid C-cell tumours observed in animal studies
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The truncation reduces IGFBP binding similar to the LR3 modification, but DES IGF-1 retains a much shorter circulating half-life (typically reported in the 20 to 30 minute range) because the rest of the molecule remains susceptible to standard proteolytic clearance
Even a small injection volume from a B12-containing semaglutide formulation delivers many times that amount, which is not a concern
