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Participants randomized to retatrutide initiated treatment with 2 mg once weekly and increased the dose in a stepwise approach every four weeks until reaching the target dose of 4 mg (via steps at 2 mg and 4 mg), 9 mg (via steps at 2 mg, 4 mg, and 6 mg) or 12 mg (via steps at 2 mg, 4 mg, 6 mg, and 9 mg)

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With so many factors to consider, the GPnotebook Shortcut below will help guide the choice of agent after metformin to ensure that the benefits outweigh the potential harm

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Clinicians can choose suitable treatment schemes based on diverse individual situations