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GLP-1/GIP chimeric peptides define the structural requirements for specific ligand-receptor interaction of GLP-1
Validated Reagents to Track GLP-1R on Immune Cells and Islets In Vivo Unlike intracellular antibodies or antibodies directed against denatured epitopes, surface-directed reagents detect physiologically accessible GLP-1R
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In people with obesity, 36 weeks of orforglipron (doses ranging from 12 to 45 mg in a phase 2 trial) resulted in a dose-dependent WL up to 14.7% compared to 2.3% with placebo, with concomitant improvement in cardiometabolic risk factors (Table 2) [25]
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