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Inhibitors like FK866 and CHS828, which are based on heterocyclic structures and act by binding to the active site of NAMPT 215,216 , are being investigated for their potential to selectively target cancer cells by exploiting their high NAD + turnover 214

WADA Status Not currently listed as a prohibited substance by the World Anti-Doping Agency, though athletes should verify current status as classifications may change

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Recently, an interesting study identified dihydroorotate dehydrogenase (DHODH) as a novel ferroptosis suppressor that functions as independent of the classical GPX4 signaling pathway and revealed the mitochondrial lipid peroxidation-dependent ferroptosis pathway [79]