But it is currently classified as a cosmetic product, meaning there is no need for it to undergo the safety testing required for medical devices
Figure 2: Around half of GLP-1 side effects are gastrointestinal GLP-1s have previously been suggested to be linked to self-harm and suicidal thoughts, but the MHRA concluded in September 2024 that the available data do not support a causal association between GLP-1s and depression, suicidal ideation and suicide, following a review by the European Medicines Agencys pharmacovigilance risk assessment committee 24
In the SURMOUNT-1 clinical trial, participants on the highest dose of Mounjaro (15 mg) lost an average of 22.5% of their body weight over 72 weeks 1
Following single administration, the elimination half-life of prototype BPC-157 was less than 30 minutes in both species, indicating rapid systemic clearance
If you are not on either medication, start bupropion first and allow four to six weeks for stabilization before beginning tirzepatide at 2.5mg weekly