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International Journal of Molecular Sciences, 23 (3), 1101
Investigators working with GHK-Cu spray are typically studying copper-peptide signaling pathways tied to collagen synthesis, antioxidant defense, and tissue remodeling
Early experiments focused on its ability to support structural integrity in gastrointestinal models
A 2016 study published in Nature Scientific Reports showed that GHK-Cu had no cytotoxicity to human keratinocytes at concentrations up to 5,800 micromolar over 72 hours and did not induce inflammatory biomarkers
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