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Early pharmacokinetic studies suggested that when standard, unprotected glutathione was ingested, it was rapidly cleaved into its constituent amino acids (glutamate, cysteine, and glycine) by digestive enzymes like $\gamma$-glutamyltransferase and harsh stomach acids
Integr Org Biol
A further challenge is off-tumor uptake and systemic toxicity
Their effects on metabolism, insulin sensitivity, and cellular growth require close monitoring and responsible use
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