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Cardiovascular Considerations Since phentermine is a stimulant, it raises heart rate and blood pressure and is contraindicated in patients with existing heart disease, uncontrolled hypertension, or a history of stroke

NK cells induce hepatic ER stress to promote insulin resistance in obesity through osteopontin production

Routine measurement of serum calcitonin levels or thyroid ultrasound screening before starting GLP-1 therapy is not recommended in asymptomatic patients without specific risk factors