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Todays market leaders include semaglutide (branded as Ozempic for diabetes and Wegovy for weight management) and tirzepatide (branded as Mounjaro for diabetes and Zepbound for weight management)
Parvalbumin-positive interneurons in the cortex and hippocampus are believed to have a key role in cognition and other higher brain functions, 32, 33, 34 and these neurons are particularly sensitive to oxidative stress
The STEP programme showed a weight loss of up to 16.9% after one year of treatment with SEMA 2.4 mg, mainly at the expense of fat mass (difference versus placebo: fat mass 3.29%
These metabolic disturbances activate several pathogenic pathways that contribute to neuronal dysfunction and death, ultimately manifesting as DPN
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