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Evidence for whether GLP-1 receptor agonists can penetrate the BBB remains limited as it has been argued that brain capillary binding or sequestration may not have been accounted for [29]

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Keller, K

Shelby Sullivan, director of the Endoscopic Bariatric and Metabolic Program at Dartmouth Health Weight Center in Lebanon, New Hampshire

Many will still need to titrate smaller doses to start - sublingual often the least reactive method