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To determine the solution structural model of the p53 TAD2 -FOXO4-DRI complex using NMR spectroscopy, we recorded several sets of NMR experiments on two types of complexes: 13 C, 15 N-labelled p53 TAD2 -FOXO4-DRI and 13 C, 15 N-labelled FOXO4-LRI D -p53 TAD2 (see methods)

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For example, according to Swoboda and Held, the mechanisms of delayed wound healing in diabetes can involve a perfect storm of vascular, cellular, and biochemical disruptions

Moi et al, 1994)

Whilst these medications offer significant therapeutic benefits, gastrointestinal side effectsincluding acid reflux and heartburnare commonly reported