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N-Acetylcysteine mucolysis in the management of chronic obstructive pulmonary disease

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For the synchronization experiments, cells were synchronized with dexamethasone (100 nM, 30 min) on day 6 of differentiation and assayed or collected at the indicated time points

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Mutations of the interfacial residues in DET1 to glycine or alanine, including R488A/H485G, R488A/H485G/R306G/S312G or R488A/H485G/E380A/T382A reduced the interaction between DET1 and COP1