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This tolerance development explains why side effects are most prominent during treatment initiation and dose escalation but decline substantially with continued use

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If each new vial from a different batch performs differently, storage during shipping could be the issue

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In the case of CCI, median and 10 th -90 th percentile were presented rather than median and IQR, as we expected a large majority of all subjects to have CCI values of 0 or 1

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doi: 10.1002/mrd.23542 23 XuZKalbfleischJD

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