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NICE guidance (NG28) specifies that these agents should generally be considered in people with a BMI 30 kg/m (or lower in certain ethnic groups) and specific problems associated with high weight, or if insulin would have significant occupational implications
Inadequacy of macro-nutrients is just one cause of fatigue, and pumping yourself with Vitamin B12 shots will not help if the root cause is unrelated to B12 deficiency
Pipeline focus: IL-17
Nat Biotechnol 25(4):465472
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