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overweight is a BMI of 25 to 29.9, according to the U.S
And is that why we see the levels that we do, that with a GLP-1 we're seeing about 15% and I think with the GLP-1/GIP combos we're seeing maybe 20 to 30% weight loss
Higher doses improve efficacy but increase side effects, particularly gastrointestinal issues like nausea and vomiting
In addition, the increased expression and activity of NOX and xanthine oxidase and NOS becoming uncoupled and structurally unstable also lead to increased ROS production [8]
Other antioxidants like vitamin C and N-acetylcysteine may also help increase glutathione concentrations
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