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GLP-1 receptors modulate incretin signaling and gastric motility
Importantly, no signals of drug-induced liver injury have emerged despite extensive real-world use, supporting the favorable hepatic safety profile of GLP-1 RAs [62]
Factors that may predispose patients to greater heart rate changes include: Higher doses of semaglutide Rapid dose escalation Significant and rapid weight loss Pre-existing cardiovascular conditions Concurrent medications affecting heart rate Dehydration or electrolyte imbalances According to FDA prescribing information, palpitations have been reported in clinical trials, though precise incidence rates vary by product and study population
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