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Larger prospective trials, stratified by hormone formulation, route of delivery, timing of initiation, and baseline metabolic health, will be required to establish causality, characterize which women benefit most, and track outcomes across the full range of health domains this article has examined

By week 68, many patients report that bowel movements return to baseline, though some residual mild loose stools may persist

For others, they can trigger painful episodes known as gallbladder attacks

Cell viability assay Cell proliferation was detected via a CCK-8 assay (Biosharp, China) or a CellTiter-Glo assay (Promega) according to the manufacturers instructions