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Discontinuation was defined as a gap of 60 days from the last GLP-1based treatment supply day, allowing for GLP-1 drug-type switching (eg, semaglutide to tirzepatide)

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15 A registry-based cohort and self-controlled case series study of 38,454 patients examined the effect of GLP-1 receptor agonists on the risk of alcohol-related events (alcohol-related hospitalizations, use of medications for AUD, and use of medications for alcohol withdrawal)

These investigations explore receptor binding behavior, intracellular signaling cascades, pathway timing, and peptide-driven molecular responses in controlled laboratory models