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In 2010, the first human trial using RNAi technology was conducted to evaluate the therapeutic effect of siRNA for targeting the M2 subunit of ribonucleotide reductase in patients with melanoma
Previous studies have confirmed that aging is characterized primarily by low-grade chronic inflammation, upregulation of senescent cells, and oxidative stress [184]
In addition, it is also related to the water solubility and fat solubility, flexibility and rigidity, and density of nanoparticles (Jiang et al., 2018)
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