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These enzymes require vitamin C to function

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Among 1203 patients with HFpEF from 11 regions in Asia, 36% of the HFpEF patients were under 55 years old, 37% were under 65 years old, and 16% were over 75 years old [22]

Ukr Khim Zh 22:603607 Pfeffer MA, Braunwald E, Moy LA, Basta L, Brown EJ Jr, Cuddy TE, Davis BR, Geltman EM, Goldman S, Flaker GC et al (1992) Effect of captopril on mortality and morbidity in patients with left ventricular dysfunction after myocardial infarction: results of the Survival and Ventricular Enlargement Trial

Genomic studies show that GHK-Cu modulates the expression of over 4,000 genes involved in tissue repair and inflammation