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Common Side Effects Nausea (typically improves after 2-4 weeks) Diarrhea or constipation Decreased appetite (this is the goal) Mild stomach discomfort Fatigue during dose increases When to Call Your Doctor Severe or persistent nausea/vomiting Signs of pancreatitis (severe abdominal pain) Vision changes Rapid heartbeat Signs of allergic reaction Is Semaglutide Right for You
NICE guidance emphasises the importance of comprehensive lifestyle modification alongside GLP-1 agonist therapy, including balanced nutrition
Clinical trials are continuing to assess its longer-term efficacy and safety across obesity, type 2 diabetes and other conditions
One of the most consequential changes in 2026 is the loss of exclusivity for semaglutide, beginning in early 2026 across major markets including India, China, Brazil, Turkey and Canada, with semaglutide having lost exclusivity in India on 20th March 2026
If approved, nerandomilast will provide another treatment option for patients with IPF, a condition with high unmet need
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