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484 participants were assessed for eligibility and 443 were randomly assigned to receive at least one dose of tirzepatide (148 [33%] in the 5 mg group, 147 [33%] in the 10 mg group, and 148 [33%] in the 15 mg group) between March 30, 2019, and Feb 16, 2021, with recruitment and enrolment continuing until Feb 4, 2020

Hormonal influences, for example, can significantly affect the healing process

Independent of weight loss, semaglutide (Ozempic) improves knee osteoarthritis by cartilage restoration, in both the mouse model and a small randomized clinical trial We used to think that the benefit of GLP-1 drugs (like Ozempic) was dependent on weight loss