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The accumulation of glucose and its metabolites in cells, for example in diabetes patients, enables this monosaccharide to interact with amino acid residues, which leads to the production of AGEs (168)
Furthermore, the meta-analysis confirmed promising effects of probiotics on the prevention as well as management of EAE (lower incidence, delayed expression of symptoms, and less severe symptoms)
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Clinical trials that successfully reduce these abnormal protein deposits have demonstrated only modest disease-modifying effects (6, 7) highlighting the continued need for additional therapeutic approaches to prevent, slow and treat AD
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