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N-acetylcysteine, an efficient thiol antioxidant and GSH precursor, was able to inhibit ATG by impeding the lipidation process of LC3 mediated by ATG4, the activity of which is modulated by hydrogen peroxide (Scherz-Shouval et al., 2007)
Therapeutic strategies aimed at restoring microbial homeostasis, reinforcing gut barrier integrity, or modulating innate immune activation such as probiotics, prebiotics, dietary interventions, fecal microbiota transplantation, and TLR-targeted agents hold promise for disease modification
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Griesi-Oliveira K, Serti AL (2017) Autism spectrum disorders: an updated guide for genetic counseling
NAC is generally well tolerated orally, with most people experiencing mild adverse effects like nausea and vomiting
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