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& Reguiai, Z
Yes, significant weight loss from tirzepatide may increase endogenous testosterone production by reducing adipose tissue aromatase activity and improving hypothalamic-pituitary-gonadal axis function
At least part of this function is via the recruitment of fibroblasts
The primary outcome was determined as achievement of 1 stage amelioration in fibrosis without progression of NASH or NASH improvement with no progression of fibrosis (as determined by liver biopsy) (NCT03486899)
In clinical trials, participants who started at 2mg and escalated every 4 weeks through 4mg, 8mg, and finally 12mg experienced a gradual onset of appetite suppression
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