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When you compromise the function of nitric oxide, insulin doesn't do its job, blood sugar goes up, and you become insulin resistant and ultimately diabetic, increasing your risk for Alzheimer's by about fourfold
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The ratio of free GSH:GSSG pools increases when egtA is deleted, and drops again upon complementation (Supplementary Table S7, Supplementary Figure S6)
Keatings lab spent many years designing peptides that would bind to the section of Mcl-1 involved in this interaction but not to other members of the protein family
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