Durability of Results: Maintenance Studies: Tirzepatide (SURMOUNT-3): Continued treatment: Additional 5.5% weight loss Stopped treatment: Regained 14% of weight Conclusion: Need ongoing treatment Semaglutide (STEP-4): Continued treatment: Maintained loss, continued losing Stopped treatment: Regained most weight Conclusion: Need ongoing treatment Phentermine: FDA-approved for 12 weeks only Weight regain after stopping is universal Not a long-term solution All Weight Loss Medications: Obesity is chronic disease Medications treat symptoms, dont cure Stopping medication weight regain Long-term or indefinite use necessary for sustained results Safety Profile Comparison: Discontinuation Due to Side Effects: Tirzepatide: 6.2% Semaglutide: 6.9% Liraglutide: 9.9% Naltrexone-bupropion: 25% (very high) Orlistat: 15-20% Phentermine-topiramate: 8-10% GLP-1s have excellent tolerability considering their effectiveness
Navya PN, Kaphle A, Srinivas SP, Bhargava SK, Rotello VM, Daima HK
While the exact foods and calorie intake vary from person to person, the overall principles remain the same: prioritise quality nutrition, stay hydrated, and build sustainable eating habits that support long-term weight management
This was thought to be due to gastroparesis secondary to GLP-1 agonist use which leads to stomach paralysis
The program is now available for self-pay patients who dont have traditional insurance, says Jamey Millar, the companys executive vice president of U.S