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They are not interchangeable in research design
The autophagy inhibitor chloroquine (CQ) combined with ADI-PEG20 significantly enhanced the cytotoxicity in sarcoma cells in vitro and CQ together with ADI-PEG20 induced sarcoma volume significantly in vivo [133]
p53 controls both apoptosis and senescence by promoting p21 transcription, resulting in cell cycle arrest during DNA repair
For individuals significantly above 250 pounds, extended protocols of 16-20 weeks rather than higher daily doses often produce better outcomes
While numerous probes have shown high sensitivity toward GSH, their selectivity over other thiols such as cysteine and homocysteine remain a major limitation
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