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Discovered in 1973 by biochemist Loren Pickart in human blood plasma, this copper-tripeptide has been the subject of over five decades of research that has progressively revealed the breadth of its biological functions
These plaques disrupt synaptic function by impeding neurotransmission and triggering excitotoxicity, leading to cognitive decline
Further structure-based iterative optimization resulting in inhibitors shown in Fig
The Journal of Steroid Biochemistry and Molecular Biology, 139 , 302-310
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