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Previous studies have indicated that the antioxidative activity and biological functions of SFN are partially dependent on the activation of nuclear factor-erythroid 2-related factor 2 (Nrf2), which is a master regulator of cellular homeostasis that is ubiquitously expressed in many organs (Houghton et al., 2016
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[00027] "Optional" or "optionally" as used herein means that the subsequently described event or circumstance can or cannot occur, and that the description includes instances where the event or circumstance occurs and instances where it does not
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