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For AD specifically, given the well-established effects of GLP-1 RAs on tau hyperphosphorylation, we recommend that future GLP-1 RA clinical trials focus on the tau-positive subgroup of patients

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The KFF 2025 Employer Health Benefits Survey then showed an even sharper acceleration: 43% of firms with 5,000+ workers now cover GLP-1s for weight loss, up from just 28% in 2024 ( [6] )