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The mechanism is not fully understood, but inflammation, abnormality of the guts mechanoreceptors and emotional states such as hypervigilance and stress likely play a role (39)

Bone 81:459467 Yang L, Yang J, Pan T, Zhong X (2019) Liraglutide increases bone formation and inhibits bone resorption in rats with glucocorticoid-induced osteoporosis

And protein is the most important nutrient for combatting such loss

J Biochem Mol Toxicol 3:e23203 Docrat TF, Nagiah S, Naicker N, Baijnath S, Singh S, Chuturgoon AA (2020) The protective effect of metformin on mitochondrial dysfunction and endoplasmic reticulum stress in diabetic mice brain

These solutions come in various concentrations, such as 0.1%, 10%, and 25%, offering an environment that can enhance the dissolution of peptides that struggle to dissolve at neutral pH