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Less than 3% of an administered dose is excreted unchanged in urine

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Here, the GIP fragments GIP(15-42), GIP(15-30), GIP(16-30) and GIP(17-30) were characterized as weak antagonists at the human GIP receptor in vitro , and the amino acids number 6-30 are required for effective GIP receptor antagonism as a high-affinity binding domain (63) ( Figure 1 )