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Carnitine inborn errors of metabolism

Liver energy metabolism reprogramming: GLP-1RA reduces hepatic glucose output by decreasing hepatic FFA uptake and the expression of key gluconeogenesis enzymes such as PEPCK and G6Pase, while promoting liver sensitivity to insulin, transforming the liver from an "energy output organ" to an "energy storage organ"

a) Insulin only b) GLP1 and GIP c) Glucagon only d) Amylin & somatostatin Answer: b) GLP1 and GIP The glucose-lowering effect is: a) Constant b) Glucose-dependent c) Hypoglycemia-prone d) Insulin-independent Answer: b) Glucose-dependent Sitagliptin is primarily excreted via: a) Feces b) Urine c) Bile d) Sweat Answer: b) Urine A rare but serious side effect is: a) Hypoglycemia b) Pancreatitis c) Hypothyroidism d) Bladder cancer Answer: b) Pancreatitis Protein binding is approximately: a) 10% b) 38% c) 80% d) 99% Answer: b) 38% DPP4 inhibitors differ from GLP1 agonists by: a) Oral vs injection b) Cost only c) Efficacy only d) Indication only Answer: a) Oral vs injection Combination with sulfonylureas increases risk of: a) Pancreatitis b) Heart failure c) Hypoglycemia d) Weight gain Answer: c) Hypoglycemia Dose scheduling is: a) Multiple times daily b) Once daily c) Every other day d) Weekly Answer: b) Once daily Sitagliptin therapy is least likely to cause: a) Hypoglycemia b) Weight gain c) Nasopharyngitis d) Pancreatitis Answer: a) Hypoglycemia Onset of action occurs within: a) Minutes b) Hours c) Days d) Weeks Answer: b) Hours Compared to saxagliptin, sitagliptin has: a) Higher potency b) Lower potency c) Similar profile d) Different mechanism Answer: c) Similar profile Sitagliptin should be dose-adjusted for: a) Liver disease b) Renal impairment c) Hypothyroidism d) Pregnancy Answer: b) Renal impairment Weight effect of sitagliptin is: a) Weight gain b) Weight loss c) Weight neutral d) Unknown Answer: c) Weight neutral Sitagliptin carries risk of heart failure

It helps you log weekly doses, injection sites, side effects, nutrition, and water in one place so you can understand and optimize your GLP1 journey

Additionally, intense inactivation of oxidative enzymes is observed, therefore protecting the sensory and nutritional quality of fruit juices and avoiding or reducing the use of antioxidants as sulphites