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Endocrine Related Cancer , 19 (5), F77
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Paradoxically, whilst long-term weight loss typically improves joint health and reduces osteoarthritis symptoms (as noted in NICE NG226), the transition period may be associated with adjustment-related discomfort
it may represent a physiologic or reactive process
In a 2001 study published in Endocrinology , Heffernan and colleagues reported that chronic AOD-9604 administration reduced body weight gain, decreased adipose tissue mass, and increased fat oxidation in obese mice without altering IGF-1 levels or glucose metabolism effects that were abolished in beta3 adrenergic receptor (3-AR) knockout mice, implicating 3-AR signaling as the mechanism of action [1]
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