Most available data are preclinical or derived from non-orthopaedic clinical contexts, and robust human orthopaedic trials were not identified
Eur J Pharmacol 158:6167, 1988 Sikiric P, Rotkvic I, Mise S, Petek M, Rucman R, Seiwerth S, Zjacic Rotkvic V, Duvnjak M, Jagic V, Suchanek E, Grabarevic Z, Anic T, Brkic T, Djermanovic Z, Dodig M, Marovic A, Hernandez DE: Dopamine agonists prevent duodenal ulcer relapse: A comparative study with famotidine and cimetidine
Common considerations include selecting a cell line or animal model known to express the innate repair receptor, establishing a concentration-response curve across a relevant range, and confirming peptide integrity via COA before each experimental run
Any yellow, brown, or hazy appearance indicates degradation
Peptides are sensitive biological molecules susceptible to degradation from bacterial contamination introduced during reconstitution