combination therapy with glp-1 receptor agonist and sglt2 inhibitor Concomitant use of inhibitors agonists in patients heart failure | Cardiovascular Diabetology – Endocrinology Reports SGLT2 Inhibitors and GLP-1 Receptor

This is beneficial in multiple ways, namely, monthly dosing after initial titration dosing, even more prolonged receptor activation along with less peaks and troughs in drug levels, which are thought to contribute to side effects

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The safety picture is built from each compound's own data plus what we know from CagriSema

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PTGS2, Prostaglandin-Endoperoxide Synthase 2