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Semaglutide has transformed weight loss treatment by activating GLP-1 receptors in the brain and gut, reducing appetite and improving metabolic control
Moreover, a large-scale randomized controlled trial (RCTs) involving more than 17,000 individuals with obesity and cardiovascular disease demonstrated that semaglutide reduced the risk of cardiovascular death, myocardial infarction (MI), and stroke compared to the placebo 9
Kidney lipid dysmetabolism and lipid droplet accumulation in chronic kidney disease
With over 11 million Canadians living with diabetes or prediabetes, and millions more affected by obesity, the potential impact is significant
Although two patients who developed VPA-related brain edema received L-carnitine and improved, no conclusion on its benefits on this major complication could be drawn
