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Initial Adjustment Period Nausea is most common during the initial weeks of treatment, particularly within the first 8 to 12 weeks

In addition to neural connections, the central clock system also synchronizes the circadian rhythms of the peripheral clock system through hormones or factors, such as arginine vasopressin (AVP) and tumor necrosis factor (TNF) ( FIGURE 1 The clock system mainly regulates metabolism in the following three ways

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Common side effects of retatrutide include nausea, vomiting, constipation, fatigue, diarrhea, headaches, and abdominal discomfort