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Why does weight often return after stopping GLP-1 drugs

Amino acid-dependent mTORC1 regulation by the lysosomal membrane protein SLC38A9

While gastric sleeve has an upfront cost, GLP-1 medications may require ongoing monthly spending for years, making the total long-term cost significantly higher for many patients

Common side effects include nausea, vomiting, diarrhea, constipation, and fatigue

When Yuyang Liu, a graduate student in his lab and first author of the study, compared SLC25A39s structure against others in the SLC family of transporters in the AlphaFold protein structure database, Liu spotted a unique extra loop in the protein