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There isnt any scientific evidence that taking berberine after a meal wont be effectivebut taking it before or with a meal is generally recommended because of the way its metabolized, and it may help lessen GI side effects
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Neurosci Lett 219: 211214
At least 6 days of recovery time was introduced between pharmacological treatments to eliminate possible residual effects from the previous treatment and to enable monitoring food intake on subsequent days (Thursdays and Fridays)
Cells (2018) 7:156
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