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Non-response at 1.5mg indicates either receptor polymorphism, prior desensitisation from chronic melanocortin agonist exposure, or incorrect administration technique

Polyvalent FRTAC nanodegraders coupling FR-binding modules to anti-EGFR or anti-PD-L1 ligands efficiently crosslink targets for lysosomal internalization

It is administered once weekly via subcutaneous injection and is being researched in late-stage trials for obesity and type 2 diabetes, but it is not yet approved

Some see subtle shifts earlier, like feeling fuller faster or having fewer food cravings (even for late-night snacks!)

Sherly Soleiman, MD discusses realistic expectations with each patient at consultation.