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Fatigue or feeling cold during fast weight loss Fewer cravings for alcohol, snacks, or junk food (commonly reported) When to Slow Down or Stop Vomiting that does not stop within 24 hours Severe upper abdominal pain that wraps around to the back Yellowing of skin or eyes Severe dehydration signs (dizziness, very dark urine, racing heart) Rapid weight loss over 2 lb per week sustained for many weeks (lean tissue loss risk) 13

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10.1016/j.ymeth.2020.07.006 118 NassarF

242 The vitamin D/VDR axis has been shown to suppress the overexpression of HIF-1 in colonic epithelial cells by regulating the NF-B pathway, thereby inhibiting the overexpression of inflammatory factors