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38 Building on previous findings, 26, 27, 37 our data support the conclusion that H4R exacerbates immunopathology in experimental colitis, but the connections to innate inflammation presents a novel H4R-regulated pathway
Studies have shown that malfunction and mutation of p53 gene may lead to an escalation in cell proliferation and a reduction in apoptosis, ultimately carcinogenesis, including gastric carcinogenesis ( Waf1/Cip1 and Bax-1 are inhibited, and suppression of p21 Waf1/Cip1 towards cyclin-CDK and proliferating cellular nuclear antigen (PCNA) is diminished, thereby activating the cell cycle
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