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The ischemia-reperfusion injury (I/R injury) of Sirt5 knockout mouse heart is restored to normal levels by dimethyl malonate (a succinate dehydrogenase (SDH) inhibitor) pretreatment, which implies that the change of SDH activity is the leading cause of the damage

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Some lipotropic mixtures will also have BCAAs, or the branched-chain amino acids valine, leucine, and isoleucine